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HCG: Urine Test and Blood Test

Dec. 24, 2020


Human chorionic gonadotropin is a glycoprotein secreted by the trophoblast cells of the placenta. It is composed of glycoproteins of α and β dimers. Human chorionic gonadotropin αβ, synthesized by syncytiotrophoblasts. The glycoprotein hormone with a molecular weight of 36700, the α subunit is basically similar to the FSH , LH and TSH secreted by the pituitary, so they can cross-react with each other, while the β subunit The structure of the base is different.


Pay attention to the difference between the two situations when Hcg Rapid Test


Hcg Rapid Test

Hcg Rapid Test


When applying HCG inspection, attention must be paid to the presence of cross-reactive substances.


Many placental chorionic hormones have similar chemical structures. They are all glycoprotein complexes, which are composed of α and β peptide chain subunits.


Moreover, the structure of the alpha peptide chain is very similar. The two have the same characteristics in chemistry, biology, immunology, etc. The commonly used HCG detection method can hardly exclude LH, but the content of LH in normal urine is very small. The method of detecting HCG is not positive, so it has little effect on pregnancy diagnosis.


However, in menopausal women, women with ovulation, and patients with bilateral ovaries removed, the amount increases, sometimes reaching 240-480IU/L. Follow-up cases of hydatidiform mole and choriocarcinoma may cause misdiagnosis under the above circumstances.


Moreover, the structure of the alpha peptide chain is also very similar. The two have the same characteristics in chemistry, biology, immunology, etc. The commonly used Hcg Pregnancy Rapid Tests can hardly exclude LH, but the content of LH in normal urine is very small. In the general method of detecting HCG, it is not positive, so it has little effect on pregnancy diagnosis.


However, in menopausal women, women with ovulation, and patients with bilateral ovaries removed, the amount increases, sometimes reaching 240-480IU/L. Follow-up cases of hydatidiform mole and choriocarcinoma may cause misdiagnosis under the above circumstances.


Certain other pathological changes can also increase HCG content.


According to reports, pituitary diseases, hyperthyroidism, ovarian cysts, endometrial hyperplasia, uterine cancer, etc. can also lead to a positive test. Others have reported that a bacterium that can produce HCG has been found in certain tumor cases.


For these situations, only relevant clinical and laboratory methods can be used to identify them. In addition, if the purity of the antibody is not enough, some cross-reactions will occur, which needs to be combined with clinical identification.


For these situations, only relevant clinical and laboratory methods can be used to identify them. In addition, if the purity of the antibody is not enough, some cross-reactions will occur, which needs to be combined with clinical identification.


If necessary, please contact the manufacturer of Hcg Pregnancy Rapid Tests Manufacturer


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